Gel Permeation and Size Exclusion Chromatography

Gel Permeation Chromatography (GPC) and Size Exclusion Chromatography (SEC) analysis providing critical information to customers via key techniques
Intertek provides chemical characterization by gel permeation chromatography (GPC) and size exclusion chromatography (SEC) for clients across industries and markets. Intertek scientists employ GPC/SEC methods to characterize polymers from aqueous and organic matrices.
Our GPC and SEC laboratories in Europe and the USA provide critical information to customers, helping speed their development of new polymer synthesis routes, processing schemes and purification techniques.
Gel Permeation and Size Exclusion Chromatography:
- Separation of polymer mixtures by size and shape
- Quantitation of mixture components in various matrices including water and organic liquids
- Measurement of average molecular weight and polydispersity of polymers
- Determination of polymer absolute mass using light scattering
- Provide support data for registering new products as polymers
- Protein Aggregation studies
- Pharmaceutical polymer excipient characterisation
Gel Permeation and Size Exclusion Chromatography Test Methods
Polymer Evaluation in n-methyl-2-pyrrolidone (NMP) and/or tetrahydrofuran (THF)
- Low Mass, High Resolution GPC up to 3,000 mass
- Low Mass GPC up to 30,000 mass
- Normal Range GPC in range of 500 – 7,500,000 mass
- Absolute mass determination in Normal Range
Polymer Evaluation in Aqueous Solutions
- Water-soluble polymers in range of 500 to 1,000,000 mass
Analysis of Amine-based Materials
- Low Mass GPC up to 50,000 mass
Wyatt Technology
- Specific refractive index (dn/dc) measurements for light scattering
- Batch light scattering measurement for molecular weight (Mw)
- Wide range of detection methods including refractive index (RI), evaporative light scattering detection (ELSD), charged aerosol detection (CAD), multi-angle laser light-scattering detection (MALLS) and viscosity detectors
- Standardization of measurements versus polystryrene (PS), polyethylene glycol (PEG), Poly(methyl methacrylate) (PMMA), polythethylene oxide (PEO) and polystyrene sulfonic acid (PSSA)
- Absolute mass using MALLs detection ensures more accurate mass determination, as well as branching information
- Aqueous Gel Permeation Chromatography
Related Gel Permeation and Size Exclusion Analysis:
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WHITE PAPERS
- Adhesives QA Testing Programs
- Food Contact & Non-Intentionally Added Substances (NIAS)
- The DoC and Regulation 10/2011 for Plastic Food Contact Materials
- Regulation EU 2020/1245 To Amend Regulation EU 10/2011
WEBINARS
- PFAS Monitoring in Environmental and Polymer Samples
- Microplastics and Nanoparticles - Definitions And Regulatory Considerations
- Microplastics and Nanoparticles and Food Contact Applications
CASE STUDIES
- Dissolution of Hydroxyapatite Coatings for Medical Devices
- Particulate Contamination control and analysis
- Polymer Rheology Testing Case Study