IADR 2025: Highlighting in vitro testing advantages

Our experts attended the IADR 2025 General Session to explore the latest innovations and scientific approaches in oral care product development, focusing on hot-topic claim areas like teeth whitening, dental sensitivity, enamel repair, and plaque control. 

We shared insights into how Intertek's advanced in vitro models—including enamel and dentine substrate testing, brush/device testing and saliva-based biofilm studies—can support early-stage formulation development, performance evaluation, and ingredient screening. These capabilities position Intertek as a valuable partner in driving evidence-based product claims and supporting clinical study success.

Read on for selected hot topics and insights from IADR 2025, shared by our expert Gavin Thomas, Laboratory Director, Intertek CRS. Questions? Schedule a call now. 

Gavin Thomas

Laboratory Director, Intertek CRS

IADR Hot Topics:

Backing Claims with Science: Enamel Repair in Focus
There is a growing interest from innovators in the use of in vitro testing that assesses the efficacy of enamel repair and protection products, particularly in evaluating remineralisation, demineralisation, and fluoride uptake. Delegates have been asking more questions on this topic and how these studies can enable them to substantiate marketing claims and support the development of innovative oral care products that meet consumer demand.
 
Precision Hard Tissue Samples for Smarter Oral Care Innovation
Dental hard tissue samples, including enamel and dentine, are crucial for optimising oral care product development, as they provide reliable substrates for assessing product efficacy in laboratory studies and clinical trials. Oral care innovators have asked our team to prepare these samples to precise specifications, enabling them to effectively evaluate performance metrics such as stain removal and remineralisation, ultimately enhancing the effectiveness of their products.

Meet our Expert
Gavin has over 20 years of experience working within the in vitro oral care sector. He is currently the Laboratory Manager at Intertek Clinical Research Services and leads Intertek’s team of scientists delivering a variety of in vitro methodologies for product evaluation and claim support.

How can our in vitro services support your product development?
Whether you are a supplier of raw materials or an oral care product innovator, in vitro oral care product testing can be an effective approach to steer early-stage formulation development, ingredient screening and selection or formulation development and performance evaluation. 

Intertek can offer a range of in vitro models to evaluate the safety and performance of oral care products or ingredients. We can also supply a range of hard tissue samples for internal R&D programmes. Finally, we can provide analytical support for oral care clinical studies.

Product Types: Our in vitro tests evaluate the following types of oral care products, toothpaste formulations, raw ingredients, mouthwash formulations, tooth gel formulations, tooth tablet or toothpowder formulations, toothbrushes, dentifrice products, interproximal cleaning devices, flosses and electronic devices such as electric toothbrushes.

Our services are targeted at the following claim areas:

Teeth Whitening: We use acellular human or bovine enamel as test substrates to evaluate the whitening efficacy of oral product formulations or ingredients. Our portfolio of tests include: pellicle cleaning ratio (PCR)  x| tooth shades whiter | stain prevention | chemical stain removal | denture stain removal | mouthwash stain removal | propensity to stain | impact upon enamel gloss | ability to restore natural tooth brightness.

Dental Tubule Occlusion: We use acellular human or bovine dentine as test substrates to evaluate the ability of oral care product formulations or ingredients to block dentine tubules, which can, according to the literature, help alleviate dental sensitivity. We utilise two models: scanning electron microscope dentine occlusion studies and/or hydraulic conductance studies.

Enamel Repair & Protection: We use acellular human or bovine enamel as test substrates to evaluate the ability of oral care product formulations or ingredients to repair and protect artificial enamel lesions. Our services include pH cycling studies, surface microhardness studies and fluoride uptake studies.

Brushes and Interproximal Cleaning: We use acellular human tooth models as test substrates to evaluate the ability of oral care devices (e.g. flosses, interdental brushes or toothbrushes) to clean the interproximal regions of teeth.

Anti-plaque: We use human saliva as a test substrate to evaluate the ability of oral care product formulations or ingredients to prevent a plaque biofilm build-up, to remove dental plaque, or to buffer the pH of dental plaque to help prevent a pH drop to levels associated with demineralisation during plaque sucrose challenges.

Safety: We use acellular human or bovine enamel as test substrates to evaluate the safety of oral care product formulations or ingredients. Our services offerings include relative dentine or enamel abrasivity tests (RDA), assessing the capacity of tooth bleaching products (ISO 28399) or bespoke studies based upon individual requirements.

Clinical Study Support: We can partner with our established CRO partners to provide analytical support for clinical studies. Our analytical services can support: oral malodour studies, bioanalytical fluoride and calcium salivary clearance studies and in situ surface microhardness studies.

Hard Tissue Samples Preparation: We are licensed by the Human Tissue Authority (HTA) to store and use human teeth for research purposes. We can prepare and supply acellular enamel and dentine samples, to support your internal R&D, as well a wide range of dental restoration materials.

RESOURCES 

Use this form to request our library of case studies or download using the links below:

• BROCHURE DOWNLOAD: Intertek Oral Care Product In Vitro Development Support Services
• CASE STUDY: Determining the Impact of a Toothpaste pH-Buffering System on Dental Plaque pH
• CASE STUDY: Efficacy Assessment of Interdental Brushes Through In-Vitro Studies
• CASE STUDY: Measuring Tooth Demineralisation and Remineralisation In Vitro
• CASE STUDY: Dentine Tubule Occlusion Studies
• CASE STUDY: Benchmarking Anti-Plaque Agents In Dentifrices And Mouthwashes
• CASE STUDY: Dentine and Enamel Block Preparation Supporting In-Vitro Oral Care Product Studies

LEARN MORE ABOUT THE IADR CONFERENCE 2025

The International Association for Dental, Oral, and Craniofacial Research will host its 103rd General Session in conjunction with the Pan European Regional Congress in Barcelona, Spain, June 25-28, 2025. This conference is a leading dental exhibition 2025 featuring presentations, workshops, Lunch & Learning Sessions, Keynote Addresses, and Symposia presented by experts worldwide. Take the opportunity to meet our team of experts, make new connections and grow your professional network.