Tooth Whitening, Anti-Stain, Stain Removal Oral Care Product Testing

Tooth whitening, anti-stain and stain removal laboratory in vitro testing to evaluate the performance of toothpastes, mouthwashes, strips, varnishes, gels or other dentifrices

Assessment of tooth whitening, anti-stain or stain removal efficacy of novel oral care products such as whitening toothpastes, stain control mouthwashes or whitening strips can accelerate product development. Consumers are driving innovation in tooth whitening products and to meet consumers' expectations of novel products and differentiate your brand in a crowded marketplace, you need to be able to demonstrate product performance through robust quantification of stain prevention, stain removal or whitening. This data is often used in the generation of marketing claims or to guide further formulation development.

In vivo, clinical studies can be expensive to commission, with costs associated with screening and compensation of large numbers of suitable volunteers as well as the training of clinical and operations staff and running costs of clinical study sites and dental surgery facilities. Volunteers are subjected to moderately invasive dental procedures and may be requested to follow restrictions in terms of diet and dentifrice use over as many as 6 months which is a long time for a volunteer to remain compliant. Inevitably, some volunteers will withdraw from the study and this must be factored in when deciding how many volunteers to enroll in the study.

Instead, a well-designed in vitro laboratory test can often yield the required data much more quickly and at a lower cost. Such studies – whether they are to support early-stage development of a product formulation or in support of marketing claims or pack claims - can be routinely carried out in our laboratory giving you the insight you need to differentiate your brand and products.

In Vitro Laboratory Studies for Anti-Stain, Stain Removal or Tooth Whitening

Our dedicated team of oral care scientists conduct robust in vitro studies using relevant models for anti-stain, stain removal, and whitening testing. We are particularly adept at designing bespoke testing for your whitening toothpaste, stain control mouthwash or whitening strip products and your specific testing needs combining visual, instrumental and photographic assessments enabling our customers to power ahead safely.

A typical anti-stain study would measure in vitro stain build-up on bovine enamel specimens following multiple exposure to test product, saliva and a specially formulated staining solution containing a mixture of tea, coffee, red wine and tobacco extract.  Relevant controls or benchmark products would be included and the test would be appropriately powered to reveal any significant product differences. Stain can be assessed subjectively by trained assessors or instrumentally using a chromameter that measures lightness and hue (L*a*b*). 

A typical stain removal study would involve staining bovine teeth or enamel specimens with a stain derived from e.g. tea and coffee and then measuring the amount of stain removal following one of several product applications.  In the case of toothpastes this could be performed using a mechanical brushing machine. We are also able to provide Pellicle Cleaning Ratio (PCR) testing whereby the abrasivity of toothpastes can be quantified against a calcium pyrophosphate standard. The degree of staining is assessed before and after treatment using a chromameter that measures L*a*b* colour parameters.  

Whitening strips or peroxide-containing gels/varnishes that remove intrinsic tooth stain can be evaluated using extracted human teeth.  Results from our studies are provided to the client in fully-signed off reports containing data tables, graphs, discussion and conclusions.

For over 20 years our Clinical Research Services group has been a trusted partner for developers and manufacturers of oral care products. We provide a one source solution for both whitening, anti-stain and stain-control studies as part of our wider in vitro oral care product laboratory testing, providing robust data to support the efficacy of novel treatments.

 
Intertek Clinical Research Services (CRS) has a dedicated in vitro laboratory which conducts testing of all aspects of Oral Care products. We are particularly adept in designing bespoke in vitro models to cater for your specific requirements. Intertek Clinical Research Services is licensed to handle and store human tissue under the Human Tissue Act 2004 and follows the principles outlined within the act as well as complying with local ethical guidelines.
Our team of laboratory scientists have a combined experience of over 30 years of testing oral care products and between them have degrees/PhD/MSc in Dentistry, Chemistry, Analytical Chemistry and Biological Sciences. They have also contributed to a variety of scientific papers in collaboration with many well-known clients and have presented posters at International scientific conferences.
 
Need help or have a question? +44 (0) 151 347 4810
 

Need help or have a question?

+44 (0) 151 347 4810
Wirral (UK):
+44 (0) 151 347 4810