Presentation Request

MONITORING OF GLYCOSYLATION USING SITE SPECIFIC APPROACHES

N-linked glycosylation is a common post-translational modification on many antibody-based biotherapeutics, and has been linked to safety, stability and activity. Modification should therefore be monitored and controlled. This presentation discusses peptide mapping and middle-up mass spectrometry as characterization techniques that give relative levels of different glycoforms, at specific sites, and compares to more common methodologies of enzymatic stripping and fluorescent labelling.

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