Case Study Download
Determining the Proportion of DNA-Packaged and Empty Capsid Populations by Cryo-TEM in Adeno-associated Viruses
Supporting the Development of Safe and Effective Gene Therapies
Viral vector purity is a major consideration in the development of gene therapies to assess safety and efficacy concerns. Robust analytical techniques are required to assess purity by determining the presence of full versus empty capsid populations in viral vectors. In this case study, Intertek expert Justine Ponzi describes the use of Cryo-TEM as a technique to determine viral vector purity through accurate quantification of full versus empty capsid populations in adeno-associated viruses.
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