Adeno-associated viruses (AAVs) are the leading delivery vehicle for gene therapies due to their high efficiency of transduction and high levels of gene expression. To ensure consistency in efficacy and safety regulatory agencies require extensive characterisation and impurity analysis of the final product. 


This webinar focuses on protein impurity analysis of the icosahedral proteic (viral protein) shell of the AAV which contains the viral genome, optimising a method that combines CE-SDS, considered the gold standard for the characterization of therapeutic proteins, with Laser Induced Fluorescence. Our expert will describe how the method is optimized for AAV2 evaluating reproductivity, specificity and sensitivity of results.


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