Chemical Imaging for Composition of Inhomogeneous Materials
Composition of inhomogeneous materials by chemical imaging using techniques including Raman, FTIR, SEM and more
Expertise in chemical imaging of inhomogeneous materials is necessary for pharmaceutical composition, packaging materials, personal care products and other samples, for expert insight into active ingredients, investigation of contamination issues, and to further product development.
While conventional optical and electron microscopy methods provide a picture of the physical structure of a material, chemical imaging can produce a picture where every point of the image has an associated data set - such as an infrared spectrum - which can be interrogated to display the variation in chemical structure across a surface or within a material.
Chemical imaging methods study and visualize inhomogeneous structures, with applications in many fields, including:
- Pharmaceuticals: imaging of polymorphic components or distributions of active ingredients in a formulation or tablet
- Packaging: imaging of surface contamination resulting in coating failure or sealing problems
- Semiconductors: visualization of surface chemistry in finely patterned substrates
- Personal care products: displaying the distribution of an active ingredient on substrates such as human hair or clothing fibres
Techniques used to generate chemical images
- Infrared Spectroscopy (FTIR)
- Raman Spectroscopy
- SEM with Energy Dispersive X-Ray Analysis (EDX)
- Confocal Scanning Microscopy
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