TIDES DIGITAL WEEK PRESENTATION REQUEST
The category of nucleic acid based therapeutics covers a vast array of molecule types, ranging in size from approximately 20 nucleotides for antisense oligonucleotides to thousands of nucleotides for mRNA based drug products. Similar analytical techniques can be applied to each type of molecule, for example chromatographic analysis for impurities, however, the approach to method design will take into consideration the different types of impurities associated with each type of molecule. Analysis of the associated delivery systems, such as lipid nanoparticles, also forms a key part of drug product testing. This presentation will give an overview and comparison of the analytical considerations for a range of nucleic acid based therapeutics.
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