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Physical Characterization Techniques for Pharmaceuticals

Industries serviced: Medical & Pharmaceutical

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Intertek ASG

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Blackley
Manchester, M9 8ZS
United Kingdom

Characterization techniques to assess the physical structure and properties of pharmaceutical compounds including APIs and formulated products.

Intertek offers physical characterization services as GLP or GMP compliant programs, to assist with QC, manufacturing trouble shooting, contamination issues and other investigations such as the identification of physical and chemical defects.  Applications include solid dosage forms, suspensions, particulates, gels and liquid emulsions. 

Molecular Level

  • Microscopy
    • Light Microscopy (IR, Fluorescence, Polarised Light, DIC)
    • Electron Microscopy (SEM, SEM-EDX, TEM, cryo-EM)
    • Scanning Probe Microscopy
    • Interferometry
    • STEM, AFM
  • Particulate level
  • Particle morphology
  • Particle size analysis
  • Dynamic Light Scattering

Bulk Level

  • Powder X-Ray Diffraction (XRD)
  • Thermal analysis (DSC, TGA)
  • Surface area, porosity, porosimetry
  • Powder flow characteristics including pourability, dustability
  • Physico-chemical properties

Powder X-Ray Diffraction can be used to study API polymorphs using morphological pure references as a comparison for the product during the development process, or as a QC test.

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