Nanoparticles in Pharmaceutical Products Analysis

Pharmaceutical nanoparticle product development support through expert analysis and characterisation services for drug delivery or diagnostic applications

Nanoparticles are being developed for a range of healthcare product applications including drug delivery, controlled release systems and medical devices. These products present multiple challenges for product characterisation that require sophisticated analytical techniques operated by experienced analysts. Intertek provides a comprehensive R&D or Good Manufacturing Practice (cGMP) compliant analytical capability for nano-sized systems for both particles or suspensions.

Application in healthcare products include nanoencapsulation of active ingredients (APIs), liposome nanoemulsions for drug delivery or dispersed metallic nanoparticulate systems applied to diagnostics applications. Intertek works with an increasing number of pharmaceutical or medical device organisations to characterize both chemical and physical properties of their nanomaterial products.

Physical Characterization:

  • Analysis of particle size and morphology using electron microscopy (SEM and TEM)
  • Particle size determination using light scattering techniques or disc centrifugation
  • Zeta potential measurements for nanoparticle interactions to aid formulation development 
  • Physical chemical properties (viscosity, solubility and more)
  • Surface area and porosity measurements by BET isotherm
  • Crystal morphology by powder X-Ray Diffraction
  • Controlled release laboratory investigations

Chemical Characterization:

  • Organic Component Analysis e.g. by using Liquid Chromatography - Mass Spectrometry (LC-MS/MS)
  • Inorganic Elemental Analysis by Inductively coupled Plasma Spectroscopy (ICP-MS, ICP-OES) or Electron Microscopy with Energy-dispersive X-ray spectroscopy (SEM-EDX)
  • Chemical information via FTIR or RAMAN spectroscopy / microscopy or Nuclear Magnetic Resonance (NMR)
  • Purity and impurities
  • Surface Chemistry / Surface Analysis (Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS), X-ray photoelectron spectroscopy (XPS)

Other Nanotechnology Services:

  • Nanoemulsion structure by cryo-SEM
  • Nanoparticles and nanoemulsions in dispersed systems by Dynamic Light Scattering (DLS)
  • Bioanalysis for nanoparticles
  • Biopolymer and biologic nanoparticles
  • Aggregation behavior of particles in solution
  • Regulatory consultancy for nanotechnology products
  • Guidance addressing potential health and environmental effects of nanomaterials 
 
 

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