Cell-Based Neutralization Assays
Intertek develops and validates a wide range of cell-based and receptor-based assays for determining the presence of neutralizing antibodies.
When an immune response to a therapeutic macromolecule is detected, cell-based neutralization assays can be employed to specifically detect the presence of anti-drug antibodies (ADAs) that interfere with the activity of the biologic in question. Each method and each compound is evaluated in a uniquely specific way in order to optimize the approach to assay development and ensure a comprehensive, scientifically sound validation.
GLP-compliant services include method development and validation for both cell-based assays and receptor-based assays, and/or combination formats for use in determining the presence of neutralizing antibodies, with subsequent analysis of clinical and preclinical samples.
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