Particulate Contamination Analysis

Particulate contamination analysis by microscopy and spectroscopy techniques to identify and mitigate contamination in chemical, industry or consumer products or processes

Identification of particulate contaminants is the first step in the resolution of potentially critical contamination problems which might occur unexpectedly at multiple points along the supply chain for many industries. Once the source is known, however, action can be taken to control and prevent future contamination.

Particulate contamination investigations encompass the identification of microscopic particles, the isolation of different particulate phases of in-homogeneous production deposits and determination of the source(s) of the various contaminants. The impact of particles finding their way into valuable samples, such as pharmaceuticals and medical devices, for example, is wide-reaching; it can mean manufacturing processes inefficiencies, compromised product quality and delays in the delivery of product to patients.

Our particular contamination analysis team adopt a strategic approach to  identifying contaminants which includes expertise in sampling and sample preparation, visual / physical examination, chemical identification and root cause analysis. Our approach is focused on delivering scientific evidence-based insight, which is essential to facilitate informed decision making and so mitigate the negative impact of particulate contamination on product quality (and safety) or production efficiency. Using microscopy techniques, contaminant particles are digitally imaged to provide forensic traceability. Following the initial microscopical assessment, analysis can be performed using Energy- Dispersive X-Ray Spectroscopy (EDX) on isolated particles using Scanning Electron Microscopy (SEM) or vibrational spectroscopy (Infra-Red or Raman), as appropriate. To characterise the size or shape of contaminating particles, photomicrography; image analysis and particle sizing are used to assess and quantify so that comparisons with “latent” or “suspect”contaminants can be made to increase the weight of evidence relating to potential sources.

Intertek offers both standardised and rapid deployment services for the identification and characterization of particulate contaminants and impurities using the following techniques:
 
•Microscopy: Light (and Polarised Light):  
Confocal Raman Microscopy
Attenuated Total Reflection Fourier-transform infrared spectroscopy (ATR-FTIR) Microscopy
Transmission electron microscopy (TEM) 
Scanning Electron Microscopy (SEM, SEM/EDX)
Molecular Spectroscopy: including Nuclear Magnetic Resonance Spectroscopy (NMR) and Raman Spectroscopy 
Surface analysis: X-ray photoelectron spectroscopy (XPS) 
Thermal analysis e.g. Differential scanning calorimetry (DSC
 
 
 Examples of particulate contamination we have helped clients resolve typically involve:
 
 • Extraneous particulates or fibers presenting as perhaps black specks within powder products or highly coloured material within a more lightly coloured product
 • Residuals from cleaning and maintenance
 • Particles observed upon dissolution or particles of different particle size and/or shape to the bulk of the material
 • Metal abrasion and corrosion leading to extraneous metal particles from pipes, pumps and vessels 
 • Particles stemming from process equipment (e.g. PTFE particles from filters, joints or gaskets)
 • Glass fragments caused by glass delamination or breakage
 • Biological matter of microbiological origin
 • Mineral particles where the manufacturing or geographic origin is important.
 • Rubber, silicone or other polymeric particles  or Teflon particles from filters, joints or gaskets
 
We have the capability to fully review analytical results and assess the findings of analytical studies focused on contamination incidents associated with production, engineering and the supply chain, providing the guidance you need to define corrective and preventive measures. Our broad experience in many industries such as the chemical, consumer products, pharmaceutical, medical device, polymer and coating sectors gives us the necessary know-how to effectively identify unknown contaminants and assist with locating their source, driving greater knowledge about supply chains, processes and products while working closely with our clients to implement necessary contamination control actions or validate legal action.
   

 

 

Whether your contamination is embedded in a solid, gel or liquid, is present in a homogeneous or heterogeneous environment, is of organic or inorganic nature or appears as fibres or crystallites, our experts apply the most suitable preparation method for your samples. 

Sampling of particles is rarely straightforward and cross-contamination has to be avoided. We can advise on proper sample collection and can suggest appropriate sample packing or can provide the proper packaging material.  

Alternatively, our experts can visit your site and take care of sample collection and transport. 

Our multidisciplinary team of experts carefully document the visual appearance of foreign particulate matter.  We utilise a wide range of techniques including light microscopy and scanning electron microscopy which are powerful tools to study the shape, morphology, size and size distribution allowing us to observe and record minute details.
Our scientists deploy microscope based techniques such as SEM with EDX which can provide valuable elemental information about the particulate chemical composition. We also apply spectroscopy techniques such as infra-red (ATR-FTIR), FTIR Imaging, Raman imaging and confocal Raman microscopy and supporting techniques such as TDS-GC/MS, GC/MS, LC/MS, NMR, MALDI-MS to study unknown particulate matter.
 

Contamination Related Service:

Need help or have a question? +1 800 967 5352
 

Need help or have a question?

+1 800 967 5352
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