Human and bovine hard tissue sample preparation and production of enamel and dentine blocks or discs for use in dental product in vitro studies
Our clients often require human or bovine hard tissue samples, prepared to precise specifications in terms of size, shape and finish. These can be supplied direct to the customer or be used in further in vitro or in situ testing to generate claims support for new dentifrice products.
Our team of scientists can produce human or bovine enamel and dentine samples in a variety of shapes, sizes and different finishes. Blocks and discs can typically be made for in vitro models and in situ clinical studies using our range of diamond abraders, wafering saws, diamond wire saws, drills and polishing machines. They can also be lapped planar-parallel using our Logitech PM5 for use in surface microhardness studies.
Enamel and dentine blocks can be made as small as 2mm square or as large as 10mm square depending on whether human or bovine specimens are required. They can be supplied individually or alternatively can be set into resin discs or blocks to make them easier to handle. Examples are bovine enamel blocks set into the bases of plastic cuvettes for use in staining and pellicle cleaning ratio (PCR) tests. For in situ studies blocks can be prepared to fit dental appliances that contain up to eight specimens at a time.
For tubule blockage experiments, dentine discs can be made with dentine tubules perpendicular to the surface. We can also produce blocks which expose the enamel/dentine interface.
For remineralisation studies we can use our diamond-wire saw to prepare thin sections of enamel 300 microns or less, hand-polished to your desired finish and mounted ready for micro-radiography.
For over 18 years our Clinical Research Services group has been a trusted partner for developers and manufacturers of oral care products. With Total Quality Assurance, we provide a one source solution for both in vitro studies and human trials providing robust data to support the efficacy and safety of novel treatments.