Ocular Tissue Bioanalysis
Ocular tissue LC-MS/MS bioanalysis laboratory services supporting ocular drugs preclinical or clinical development
Intertek's ocular tissue LC-MS/MS bioanalysis experience extends over a decade in regard to development and highly optimised validation for a wide variety of compounds in multiple ocular matrices of different species which adhere closely to regulated bioanalysis guidance.
A diverse platform of homogenization and extraction techniques is available for processing ocular tissues and fluids to ensure optimal recovery of analytes. Technologies such as multi-tube bead homogenization and high energy ultrasonication are often employed individually, or in conjunction with more traditional processing techniques.
Non-GLP studies are also routinely conducted to support discovery, lead optimization and proof of concept programs of ocular drugs.
Methods have been validated in the following ocular matrices:
- Aqueous humor
- Vitreous humor
- Iris ciliary body
- Lacrimal gland
- Trabecular meshwork
- Eye lid
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