Oligonucleotide Analytical Services

Oligonucleotide analysis and characterisation for pharmaceutical development.

Our comprehensive analytical capabilities and experience to support the development of oligonucleotide therapeutics include GLP or cGMP characterisation services for the different classes of oligo-based drugs (siRNA, Antisense oligonucleotide (DNA-like) or Aptamer). Services are available to support the product development pipeline from analysis of preclinical materials through to GMP batch release testing requirements.

Specialist oligonucleotide therapeutic analysis:  

• Oligonucleotide sequencing and proof of structure studies
• Oligonucleotide mass spectrometry. Detailed characterisation of oligonucleotide impurities using MALDI-MS, LCMS / LCMSMS including computational tools to aid interpretation
• Characterisation of double stranded oligonucleotides (DNA and RNAi)
• ³¹P NMR characterization of Nucleotide phosphonates, phosphoramidites and oligonucleotides
• ³¹P NMR analysis of product related phosphorous containing impurities
• Elemental Analysis and Trace Metals 
• Pharmaceutical Organic Volatile Impurity Analysis  

Request more information to see how Intertek can help your organization with Oligonucleotide Analytical Services.