Analysis of fluoride, potassium, calcium or zinc in plaque or saliva samples using ICP-MS or ion-selective electrodes, for product delivery studies & oral clearance
The analysis of fluoride, potassium, calcium or zinc in saliva or plaque yields useful information about the delivery of these agents from toothpastes and mouthwashes and their subsequent clearance from the oral cavity.
Dentifrice products are formulated with a variety of therapeutic agents designed to provide the consumer with clinical benefits. Common examples are fluoride and calcium for the repair and protection of tooth enamel, zinc as an anti-plaque, anti-calculus and anti-malodour agent and potassium to combat dentine sensitivity.
It is important to understand how these agents are released from products when they are used, how they disperse in the mouth, where they are delivered to and how long they persist in the mouth. Such understanding can help guide product formulation and development.
Our clinical team can work with you to design delivery and clearance studies involving fluoride, potassium, calcium or zinc in plaque or saliva. These studies are carried out according to Good Clinical Practice (GCP) as defined in clinical and analytical protocols. Typically volunteers will attend one of our testing facilities and remain on-site for the duration of product use and clearance from the oral cavity (up to 4 hours).
Samples of plaque (>2mg) or saliva (>0.5mL) are immediately shipped to our own team of laboratory analysts where they can be stabilized and analysed for the particular ions of interest. We commonly use ion-selective electrodes for analysis of saliva samples. Plaque samples can be analysed using inductively coupled plasma spectroscopy with optical emission spectroscopy detection (ICP-OES).
All data is quality checked before submission of a detailed report incorporating full statistical analysis, graphs and tables.
For over 18 years our Clinical Research Services group has been a trusted partner for developers and manufacturers of oral care products. We provide a one source solution for both in vitro studies and human trials providing robust data to support the efficacy and safety of novel treatments.