Dental Abrasivity Clinical Studies

Dental abrasivity clinical studies conducted to assess the abrasion potential of toothbrushes and toothpastes by experienced dental investigator

Dental abrasion is a potential result of rigorous tooth brushing with abrasive dentifrices and as there is a consumer demand for toothpastes and toothbrushes designed specifically for stain removal or tartar control (supragingival calculus removal) this area is gaining increasing interest for manufacturers.

The potential abrasive nature of these products on soft and hard dental tissues must be assessed during safety and efficacy studies. Dental abrasivity clinical studies conducted under strict clinical trial controls, are critical to objectively assess the abrasion potential of toothbrushes and toothpastes. 

Our in-situ models allow assessment of enamel and dentine abrasion on real dental tissue, subjected to the rigors of a normal oral environment in a controlled clinical trial. Example methodologies include in situ enamel wear, in situ dentine wear and in vivo tooth brush abrasion (soft tissue).

We use risk-based approaches for dental abrasivity clinical trial design and  participant screening and recruitment, establishment of a baseline, supervised brushing, participant dosing, oral care examinations, clinical data collection and management, statistical data analysis and comprehensive reporting. 

Our participant database is one of the largest and fully characterised in the industry and currently includes over 12,000 participants. Subjects receive clear instruction on how to use the products either during supervision at our clinical test site or at home. 

The robust clinical data generated from our oral care clinical studies provides statistical effectiveness against claims. The programs we design generate the high-level of evidence and the insight you need to drive decision-making as part of new product development in oral care.

For over 20 years our Clinical Research Services group has been a trusted partner for developers and manufacturers of oral care products. Our laboratories also provide in house comprehensive in vitro oral care product testing and bioanalytical solutions including in vitro dental abrasivity assessments, bioinstrumentation, imaging and sampling techniques. 

 
 
Our team of full-time dental assessors use industry recognised dental indices to measure stain and whitening during clinical studies, assessing effectiveness against claims where required. We conduct over 35 oral care clinical studies per year, which means that examiners’ assessment skills are utilised regularly. With regular, structured calibration programs we ensure consistency amongst assessors and provide robust data to measure variability among and between our assessors which enables optimization of our clinical assessment processes.
Intertek clinical research facilities comprise five sites in the UK that offer an optimal blend of practicality and flexibility. All sites have the capability to accommodate studies in different indications with high quality clinical spaces including oral care suites, private examination rooms, interview areas, sample preparation and dosing stations. The versatility of our sites and staff allow us to maximize project scheduling opportunities by providing equivalent facilities and skills across a variety of locations.
 

Need help or have a question?

+44 (0) 151 347 4810
Wirral (UK):
+44 (0) 151 347 4810