In Vitro Oral Care Product Evaluation

In-Vitro Oral Care product studies, including evaluation of toothpastes, toothbrushes, and mouthwashes, as well as bespoke design of cleaning, whitening, abrasion and active agent delivery models.

Intertek 4-Front Research provides an experienced team of analysts and cross-category scientists able to assist with a variety of services in support of in vitro oral care clinical studies.

In vitro oral care study capabilities include: 

• Human and bovine hard tissue sample prep (enamel/dentine)
• Fluoride analysis of tissue and saliva samples using ion-selective electrodes
• Microhardness evaluation of human/bovine enamel
• Abrasivity / tissue loss using 2-D probe profilometry
• Whitening analysis using various chromameters
• Plaque/saliva sample preparation for active agent analysis
• Oral malodour assessment using GC / OralChroma / Halimeters
• Operation of Periotrons for Gingival Crevicular Fluid analysis

Intertek 4-Front Research provides in vitro oral care product assessment using a wide variety of methods, which include: 

• Enamel and dentine block preparation to customers required specification
• Plano-parallel sample prep using diamond wire saw, abraders and Logitech PM5 lapping machine
• Artificial stain preparation and whiteness evaluation
• In vitro “lissajous” pattern brushing machine with variable loadings and speeds
• Artificial lesion preparation using acid gels
• Cutting, polishing and mounting of thin lesions with access to radiographic analysis
• Microhardness evaluation using Vickers and Knoop indenters
• In vitro cleaning evaluation of toothbrushes, interdental brushes, flosses and tapes
• Image analysis for cleaning quantification
• Fluoride delivery models

Intertek 4-Front Research is licensed to handle and store human tissue under the Human Tissue Act 2004 and follows the principles outlined within the act along with local ethical guidelines.

Contact us to see how Intertek can help your organization with In Vitro Oral Care Product Evaluation.